I finished House of Leaves last night.

I read through the whole thing at night, in varying states of exhaustion.  Serin tells me that he read it mostly while drinking.  I assume they both enhance the experience in similar ways.

( ***SPOILER*** THEORIES THAT GIVE AWAY LARGE PARTS OF THE ENDING(S) OF THE BOOK ***SPOILER*** If you haven't read it yet and don't want to know the ending(s) ahead of time, DON'T CLICK THE TAG. )